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Emulsion spray-drying for the preparation of albumin-loaded PLGA microspheres |
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| Abstract | The purpose of this work was to study the encapsulation of bovine serum albumin (BSA) in polylactide-co-glycolide (PLGA) microspheres by using an emulsion/spray-drying method. Albumin was dissolved in an aq. phase (w) in the presence of a surfactant and emulsified in an org. phase contg. the polymer (o). To stabilize the emulsion, different types of surfactant (Pluronic F68, Pluronic F127, sodium oleate, dioctyl sodium sulfosuccinate) were added to the aq. phase. The w/o emulsion was spray-dried to obtain BSA-loaded PLGA microspheres. The effect of type of surfactant on microsphere characteristics was evaluated. The microspheres were characterized for their morphol. by SEM (SEM) and granulometric anal.; drug content detn. and in vitro dissoln. tests were performed. The emulsion/spray-drying method is suitable for obtaining small microparticles (2-5 mm) characterized by high drug payloads (70%-80% encapsulation efficiency). The type of surfactant affects the microsphere shape and BSA release behavior. | |
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| Altri Autori | Giunchedi Paolo Conti Bice Genta Ida Conte Ubaldo |
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