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Ricerca >> Gruppi di Ricerca >> Gruppi della Sezione Chimica Farmaceutica >> Scheda pubblicazione
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Amidinobenzisothiazole Derivatives with Antidegenerative Activity on Cartilage |
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| Abstract | New N-(benzo[d]isothiazol-3-yl)amidines were synthesized and evaluated for their antiinflammatory activity. Encouraging results led us to evaluate these derivatives on the prevention of cartilage destruction in articular disease. Antidegenerative activity was assayed on culture of nasal pig and diarthroidal joint human cartilage in the presence of interleukin-1beta (IL-1beta). The amount of glycosaminoglycans (GAGs) and the production of nitric oxide (NO) in the culture medium were determined. The obtained results showed that all the compounds, in the presence of IL-1beta, blocked the cartilage breakdown, with different behaviour. The antidegenerative activity is more evident in human cartilage. Il Farmaco 57, 671-675, 2002 | ||
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| Altri Autori | Venera Cardile, Paola Vicini, Matteo Incerti | ||
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